PHAC 4001 Lecture Notes - Lecture 26: Bronchial Hyperresponsiveness, Intercostal Muscle, Asthma

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Phac 4001 lecture 26 march 22, 2021 immunopharmacology and anti-viral drugs ii. Lung function and physiology: sole purpose is gas exchange of oxygen to alveoli and remove carbon dioxide from alveoli. Intercostal muscles between ribs and diaphragm contract, rib cage expands creating negative pressure and drawing air into the lungs. In canada, approximately 20 children and 500 adults die each year from asthma: can"t be cured, but can be controlled. Influence susceptibility to develop asthma in predisposed individuals, precipitate asthma exacerbations, and/or cause symptoms to persist. Indoor allergens: outdoor allergens, air pollution, respiratory infections. Predispose individuals to, or protect them from developing asthma: genetic predisposition toward the development of immediate hypersensitivity reaction, airway hyperresponsiveness, gender, race/ethnicity. Irritants: temperature change, exercise, strong odors, stress and emotions, cold air: others: medication, tobacco, food additives, gastric reflux, pollutants, respiratory viral infections: most common precipitant of asthma exacerbations among children <5 y/o.

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