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BIOL 112 Lecture Notes - Lecture 11: Citric Acid Cycle, Electron Acceptor, Reduction Potential

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School
McGill University
Department
Biology
Course
BIOL 112
Professor
Frieder Schoeck

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BIOL 112 Full Course Notes
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BIOL 112 Full Course Notes
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Document Summary

Oxidation of pyruvate to acetyl coa in mitochondria, releasing. Finish glucose oxidation by converting acetyl-coa to 2 co2. C2 added in first reaction, co2 splits off in following oxidation reactions. Results in 3 nadh, 1 fadh2 (reduced e - carriers) and 1 gtp= Add citric group to acetyl coa to generate citrate. Catalyzed by dehydrogenases (remove h atoms) are redox, Oxidation of c compound coupled with nad reduction. Fad used as nad cannot be reduced by oxidation of succinate to produce fumarate (on redox chart, potentials would cause reverse reaction with nadh) Have same redox potential, but concentration of fumarate is low which drives reaction of electrons to oxidize succinate. Main purpose: generate reduced electron carriers for etc. Using nadh to produce atp and nad + so it can be recycled in citric acid cycle. Series of redox reactions coupled to protein transport across mitochondrial cristae membrane into intermembrane space.

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Related Questions

___ 25- The Krebs cycle begins with the union of acetyl CoA with oxaloacetate forming citrate, allowing oxidative decarboxylation reactions to occur, and ends with the conversion of malate to oxaloacetate. Using this information and your knowledge of the Krebs cycle, how many net carbons does the citric acid cycle gain?
A) 0 carbons
B) 1 carbon
C) 2 carbons
D) 4 carbons
___ 26- Directly from the Krebs cycle we can obtain:
A) ATP
B) GTP and NADPH
C) ATP and NADPH
D) ATP, GTP, and NADPH
___ 27- Which of the following is not an intermediary of the Krebs cycle?
A) oxaloacetate
B) citrate
C) succinyl CoA
D) acetyl CoA
___ 28- How many di nucleotides are reduced by four turns of the Krebs cycle?
A) 1 FADH2 and 4 NADH
B) 2 FADH2 and 8 NADH
C) 4 FADH2 and 12 NADH
D) 1 FAD and 4 NAD +

_____What is added to a molecule such as ADP when it is phosphorylated?

_____ An anaerobic process in which pyruvate is converted to lactate

_____ A biochemical process that breaks down food molecules to produce other molecules for cellular maintenance.

_____What is the final end product of Glycolysis?

_____ Refers to the potential energy provided by a large hydrogen-cation concentration gradient, and it’s movement across a biological membrane during chemiosmosis.

_____ A molecule that transfers or shuttles electrons during redox reactions.

_____ An organism that can survive in the presence or absence of oxygen.

_____ A type of enzyme that teams with NAD+ to remove hydrogen atoms with their electrons.

_____ The loss of electrons from one molecule to another.

_____ A process in which ATP is produced using the energy stored in concentration gradients.

_____ The products produced during a biochemical reaction that fall between the starting molecule and the end product.

_____ Biochemical process in which a glucose molecule is degraded to two pyruvates.

_____ Short for “reduction/oxidation” reactions

_____How many pyruvate molecules are produced from a single Glyceraldehyde 3-phosphate?

_____ The formation of ATP occurring when an enzyme transfers a phosphate group from an organic molecule to ADP.

_____ Organisms that will die in the presence of oxygen.

_____ A term referring to the presence of oxygen.

_____ A series of electron-carrier molecules that shuttle electrons during the redox reactions that release energy used to make ATP.

_____ A biochemical process in which pyruvate is produced without the presence of oxygen.

20._____ The metabolic cycle that is fueled by Acetyl CoEnzyme A; occurs in the matrix of the mitochondria and supplies most of the NADH molecules that carry energy to the electron transport chain.

_____What is the chemical formula for Cellular Respiration?

_____What environmental condition is necessary for Anaerobic Respiration to occur?

_____Where does the Electron Transport Chain occur in the mitochondria?

_____Where does Glycolysis occur in a cell?

_____ An anaerobic process in which CO2 is released as a byproduct and ethanol is produced as a product.

_____Where does the Krebs cycle occur in the mitochondria?

_____ The gain of electrons from one molecule to another.

_____ A high-energy fuel molecule that begins the Citric Acid Cycle.

_____What condition is necessary of Aerobic Respiration to occur?

_____ A term referring to the absence of oxygen.

_____What compound is derived from B vitamins, and helps the Acetyl portion of Acetyl CoA into the Krebs Cycle?

_____What is the name of the molecule that channels protons, providing the energy necessary to phosphorylate ADP to ATP?

_____In the blank, write the number of ATP’s that can be synthesized from 3 NADH molecules.

_____In the blank, write the number of ATP’s that can be synthesized from a single FADH2 molecule.

_____What is the final electron acceptor in cellular respiration?

_____What molecule is regenerated during the process of the Krebs Cycle?

_____What enzyme is used to catalyzed the reaction that occurs during the formation of Acetyl CoA?

_____How many pyruvates are produced from a single glucose molecule?

_____How many Acetyl CoA molecules are produced from a single glucose molecule?

_____What is the reduced form of Nicotinamide Adenine Dinucleotide?

_____What is the oxidized form of Flavin Adenine Dinucleotide?

42._____ A membrane protein that is used in conjunction with chemiosmosis to produced ATP.

I know that this alot of questions, but it's kinda a last ditch effort. these are the last 42 definitions i have left to answer out of 500 question for my final exam study guide. so whatever help i can get is fine. No explanations needed just what each definition is explaining and thanks in advance ladies and gentlemen.

1. C6H12O6 + 6O2 Ã 6CO2 + 6H2O Glucose is being _____ to _____ and oxygen is being _____ to _____. a. oxidized; carbon dioxide; reduced; water b. oxidized; water; reduced; carbon dioxide Incorrect c. reduced; water; oxidized; carbon dioxide d. reduced; carbon dioxide; oxidized; water

2. Which of the following stages in the breakdown of the piece of toast you had for breakfast generates the most ATP? a. the citric acid cycle Incorrect b. glycolysis c. the digestion of starch to glucose d. oxidative phosphorylation

3. Which of the following is a catabolic pathway? a. gluconeogenesis b. production of starch Incorrect c. glycolysis d. production of glycogen

4. Per molecule, the oxidation of a fatty acid results in _____ energy storage than the oxidation of glucose. a. the same b. less Incorrect c. more d. None of the above; fatty acids cannot be oxidized.

5. Of the eight reactions in the citric acid cycle, how many are oxidation-reduction reactions? a. one b. two c. three d. four e. five

6. The process of glycolysis transfers the energy in sugar molecules into the stored energy of activated carriers such as ATP and NADH. Which statement is true about glycolysis? a. Only eukaryotic organisms do glycolysis. b. The ten reactions of glycolysis are identical in all eukaryotic cells, but are different in prokaryotic cells due to their diverse metabolic strategies. Incorrect c. The ten reactions of glycolysis are identical in almost all living organisms on the planet. d. There are many ways to oxidize glucose and transfer energy into activated carriers; the diversity of organisms on the planet is reflected in the diversity of their mechanisms of glycolysis.

7. Referring to the sentence completed in #13 above, the purpose of the latter reaction (in active muscle cells) is to _____. a. accumulate lactic acid in the cell, which provides additional energy for the production of ATP Incorrect b. slow down glycolysis until oxygen becomes available again c. accelerate the Krebs cycle, which will restore the oxygen supply d. regenerate NAD+ so that glycolysis can continue in the absence of oxygen

8. What are the products of the citric acid cycle? a. carbon dioxide, NADH, FADH2 and GTP b. carbon dioxide, NAD+, FAD and GTP c. NADH, FADH2, and acetyl CoA Incorrect d. carbon dioxide and water

9. Which statement is true about enzymes? a. Enzymes catalyze chemical reactions because they make inherently endergonic reactions exergonic. b. Each enzyme in a cell can catalyze many different chemical reactions involving chemically different substrates. Incorrect c. Enzymes can only catalyze reactions in one direction. d. After catalyzing a reaction, an enzyme is permanently altered and can no longer bind substrate. e. None of the above is true. 1

10. ∆G measures the change in free energy in a system as it converts reactant (Y) into product (X). When [X] = [Y], ∆G is equal to _____. a. RT b. ΔG° + RT c. ΔG° d. ln [X]/[Y]

11. The ∆G° for the hydrolysis of ATP is -7.3 kcal/mol. What conditions in the cell would lead to a ∆G for ATP hydrolysis of -11 kcal/mol? a. An increase in the ATP/ADP ratio b. An increase in anabolic activity in the cell c. Transport of ATP out of the compartment where the reaction is occurring Incorrect d. A decrease in the ATP/ADP ratio

12. In the first reaction of glycolysis, a phosphate transferred from ATP to a glucose molecule to produce glucose-6-phosphate and ADP. Under conditions existing in the cell, the free energy change for this reaction is -8.0 kcal/mole. Which of the following statements is true? Recall that the ∆G° for the hydrolysis of ATP is -7.3 kcal/mol. a. Glucose concentrations in the cell are always low, making this reaction more favorable than would be expected. b. This reaction is less favorable than would be expected, given the ∆G° of ATP hydrolysis. c. Glucose-6-P concentrations in the cell are very low relative to glucose concentrations, making the reaction more favorable than would be expected. d. The ∆G° for the addition of a phosphate to glucose must be -0.7 kcal/mole.

13. Protein E can bind to two different proteins, S and I. The binding reactions are described by the following equations and values: E + S --> ES Keq for ES = 10 E + I> EI Keq for EI = 2 Given the equilibrium constant values, which one of the following statements is true? a. When S is present in excess, no I molecules will bind to E. b. E binds I more tightly than S. c. The binding energy of the ES interaction is greater than that of the EI interaction. d. Changing an amino acid on the binding surface of I from a basic amino acid to an acidic one will probably make the free energy of association with E more negative.