BIOL 201 Lecture 14: Lecture 14 notes
29 Jul 2016
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Cancer is biggest killer in canada (1/4 canadians will die from cancer) Ovarian, pancreatic, prostate you don"t know you have it until really late. Lung cancer kills more people each year than breast, colon and prostrate cancers combined; 70% of lung cancers are smoking associated. If you begin the cell cycle, you cannot stop the cell if it"s past the go point aka restriction point: growth factors make a difference in g1 phase. Growth factors will bind to cell, transduce signal through the membrane and tell the nucleus it"s time to divide. Growth factors have to be present before the dna damage checkpoint. There is a constant growth inhibition signal ie: when cells touch, don"t divide. The regulation of these checkpoints is the reason most cancers happen. Cdk4-cyclin d, cdk6-cyclin d > cdk2-cyclin e . > cdk2-cyclin a > cdk1-cyclin a, cdk1-cyclin b.
