BIOL 300 Lecture Notes - Lecture 3: Rna Polymerase I, Nuclear Transport, Small Interfering Rna

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Biol 300 / lecture 3 : eukaryotic rna polymerases and formation of the pol ii pre- initiation complex (pic) Moon / monday september 11th, 2017 (fall 2017) The basic state of transcription in prokaryotes is therefore on , and is repressed by repressor proteins when needed. In eukaryotes, there has to be a lot of transformation to occur before genes can be transcribed. Genes in highly condensed regions (heterochromatin) tend not to be expressed. These parts of dna are hidden when part of this condensed complex of chromatin. Genes in more open (euchromatin) are more readily expressed and available for binding of the transcription apparatus to dna. In sum, the context in which the dna is kept is very different in prokaryotes and eukaryotes. In higher eukaryotes, much of the dna is non-coding, both within and between genes (e. i large intergenic regions of introns).

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