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Lecture 7

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Biology (Sci)
BIOL 201
Greg Brown

Lecture 7 Pyruvate Oxidation and the Kreb’s Cycle Pyruvate dehydrogenase converts pyruvate into acetyl-coa. Acetyl of the acetyl-coa becomes CO2 while in the kreb’s cycle. Pyruvate Oxidation Process takes place in the matrix of the mitochondria. Succinate dehydrogenase is a part of the inner membrane. The other enzymes are found in the matrix. In the process of oxidizing acetyl-coa into CO2, NADH and FADH2 are produced. 1 GTP is formed during this process (substrate level phosphorylation). GTP is eventually used to phosphorylate ADP into ATP. The bond between the acetyl group and the coa is high in energy, when broken produces a lot of free energy to be captured. NADH and FADH2 produced are eventually reduced back into NAD and FAD. This process is worked by the electron transport chain, which is based upon a proton gradient that allows the gradient’s energy to be used to phosphorylate ADP. Pyruvate dehydrogenase is made up of 3+ proteins. The complex oxidizes pyruvate into acetyl, which is combined with CoA. From 3 carbon unit to 2 carbon unit. This process is nearly irreversible, the equilibrium favours greatly to the acetyl-CoA, due to significant regulation. E1 (thiamine pyrophosphate) is a cofactor for decarboxylation. E2 (lipoic acid), and E3 (FAD). E1 forms a link between thiamine pyrophosphate and a hydroxyethyl group. This is then combined with lipoic acid linked to a lysine. The E3 then reoxidize the thiamine-E2 complex, crea
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