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CHEM 183 (143)
Lecture

Pain and Anesthetics

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Department
Chemistry
Course
CHEM 183
Professor
David Harpp
Semester
Fall

Description
November 15 Pain and Anesthetics 1. Remarks about pain 2. Relief of pain – anesthetics 3. Pain research  Some people do not experience pain – it’s called congenital analgesia. They often can feel touch but not always temperature.  Francis Thompson 1859 – 1907 drug addict wrote a remark about pain  Emily Dickinson wrote about pain  1/5 persons suffer from chronic pain  ¼ persons over age of 65 suffer from chronic pain  No device to measure pain. It is what the person says it is.  Acute pain: results from disease, inflammation or injury – confined by time  Chronic pain: persists – representing the disease itself.  The more the pain, the longer it takes to recover  “think of pain as a disease”  The spinal cord “rewires” itself when there is pain. Pain can become permanent.  10 point pain scale in hospitals  Lebenswecker redirects the pain. o Needles at the end  Classic drug for pain: morphine – Morpheus (God and dreams) o Not addictive if given for pain (usually) o From poppy, contains opium, a narcotic  Thomas DeQuincey: Confessions of an Opium Eater (1822)  “surgical” methods prevailed for pain relief where morphine was unavailable. o Trepanation  Orthopedic surgeons were far many years all male. Now 5-10% are female. (before it required a lot of strength: the saw)  Anesthetics were needed  First anesthetic: ether o Raymundus Lullius from Spain 1275 produced sweet vitriol. H SO 2 4 o Vallerius Cordus from Germany 1540s also produced sweet vitriol o Claims!  Paracelsus born 1493. Kept records associated with ether. Wrote in a special code  CH -3H -O2H: ethanol. Heated in the presence of an acid, water is lost, ether is formed.  Ether: CH 3H -O2CH CH 2 3  Joseph Priestley 1772 created N 2 o Ammonium nitrate (a fertilizer, an explosive, a crystalline solid) is heated to create N2O and water. November 15 o “laughing gas” o Gave a high and then pass out o Propellant for whipped cream  Dr. Crawford Williamson Long 1842 credited for ether. 2 tumours removed.  Late 1800s nitrous oxide routinely used for dentists  William T. G. Morton 1846 used ether. He called it Letheon. Lethe was a river in Hell. If drunk, one would forget all and spend eternity remembering nothing of life.  Ether was bottled. Quite volatile.  John Collins Warren 1846 contacted by Morton; Massachusetts General Hospital. o Ether Dome  Two main operations of this era: 1. Amputation
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