MIMM 214 Lecture Notes - Lecture 22: Interleukin 22, Plasma Cell, Egg Cell
15 Mar 2017
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But it"s actually tfh: promotes production of neutralizing antibodies and class switching, same as with the above point. Important role in response to parasitic helminths: recruits and activates granulocytic cells including eosinophils, mast cells, and basophils, dysregulated th2 responses are involved in allergies. Th2: signal 3 and effector cytokines: signal 3 is il-4, the effector cytokines produced by effector th2 cells are il-4, il-5, and il-13. Th2: signaling and master transcriptional regulator: signal 3 signals through stat proteins, induces transcription of gata-3, the master transcriptional regulator which also acts as a tf to induce transcription of the effector cytokines including il-4, il-5, and il-13. Th2 cells: secrete il-4, il-5, & il-13, recruits granulocytes: eosinophils, basophils, mast cells, microbes targeted: to aid in killing of helminth parasites. Parasitic helminths: multicellular worms, colonize gut of animals and humans all over the world (1 billion people currently infected with a helminth!, often cause chronic infection.
