MIMM 214 Lecture Notes - Lecture 6: Neutrophil Extracellular Traps, Opsonin, Organelle
7 Jun 2018
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Lecture 6 – January 16, 2017
Innate Immunity
- Primary line of defense
- Immediately available
- Mostly mediated by leukocytes other than lymphocytes
o Phagocytes
▪ Macrophages and its tissue specific variants
▪ Immature dendritic cells
▪ Granulocytes (eg neutrophils)
o Natural killer (NK) cells
- Does ot get etter with eposure o eor
- No fine specificity
Take home messages:
- Pathogens enter through mucosal and epithelial surfaces
- Many types of pathogens
Tissues and physical elements
- Epithelial surfaces of the body provide the first barrier against infection
o Skin
o Gut epithelium
o Respiratory epithelium
- Saliva, hair, mucus, tears → all provide innate immunity
Cellular elements
- Neutrophils and other granulocytes
- Monocytes & macrophages (tissue-specific variants: Kupffer cells, microglia, intraglomerular
esagial ell…
- Dendritic cells
o Immature DCs
o Mature DCs
▪ Conventional DCs
▪ Plasmacytoid DCs
- Natural Killer (NK) cells
Chemical elements
- Enzymes (eg lysozyme → digest peptidoglycan)
- Anti-microbial peptides (eg defensins → disrupt cell membrane)
o Defensins brought by electrostatic forces
- Complement
Infectious agents must overcome innate host defenses to establish a focus of infection
Migration of innate cells to site of infection
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Document Summary
Mostly mediated by leukocytes other than lymphocytes: phagocytes, macrophages and its tissue specific variants, granulocytes (eg neutrophils) Immature dendritic cells: natural killer (nk) cells. Does (cid:374)ot get (cid:862)(cid:271)etter(cid:863) with e(cid:454)posure (cid:894)(cid:374)o (cid:373)e(cid:373)or(cid:455)(cid:895) Epithelial surfaces of the body provide the first barrier against infection: skin, gut epithelium, respiratory epithelium. Saliva, hair, mucus, tears all provide innate immunity. Monocytes & macrophages (tissue-specific variants: kupffer cells, microglia, intraglomerular (cid:373)esa(cid:374)gial (cid:272)ell (cid:895) Immature dcs: mature dcs, conventional dcs, plasmacytoid dcs. Anti-microbial peptides (eg defensins disrupt cell membrane: defensins brought by electrostatic forces. Infectious agents must overcome innate host defenses to establish a focus of infection. Migration of innate cells to site of infection. Monocytes and neutrophils recruited to site of infection. Some blood clotting can happen in micro vessels to prevent pathogen from spreading out from initial site. Monocytes recruited to site of infection via adhesion molecules. Can be expressed on immune cells, on tissues.
