MIMM 214 Lecture Notes - Lecture 6: Granulocyte, Natural Killer Cell, Microglia

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Mostly mediated by leukocytes other than lymphocytes: Immediately available in an immune response: phagocytes. Granulocytes (e. g. neutrophils which are the most important of them with respect to phagocytosis: natural killer (nk) cells. Does not get better with exposure (no memory) Pathogens enter through mucosal and epithelial surfaces. Epithelial surfaces of the body provide the first barrier against infection: skin, gut epithelium, respiratory epithelium. Saliva, hair, mucus, tears all provide innate immunity. Burn victims can be very susceptible to infections and so can, people with issues with their epithelial surfaces. Monocytes & macrophages (tissue-specific variants: kupffer cells, microglia, intraglomerular mesangial cells, etc. ) These can produce anti-viral cytokines in large amounts. Anti-microbial peptides (e. g. defensins disrupt cell membrane of bacteria: electrostatic attraction and the transmembrane electric field bring the defensin into the lipid bilayer, defensin peptides then form a pore. Infectious agents must overcome innate host defenses to establish a focus of infection.

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