PATH 300 Lecture 3: L3_PATH-300
11 Mar 2018
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Document Summary
Can be abnormally triggered or prevented in disease. It does not involve inflammation (unlike necrosis; not as obvious). It involves rapid & total removal of cells and is referred to as programmed cell death . When triggered, it requires the active synthesis of both rna and protein. Cell begins to come apart in apoptosis into membrane-bound fragments. It inserts new signaling molecules that tell the neighboring cells to phagocytose. Apoptotic bodies have ligands for phagocytic receptors that are recognized by neighboring epithelial cells or macrophages and ingested. Occurs normally in skin, intestine, uterus, infected cells, lens of eye, etc: e. g. , occurs very frequently in the embryo and fetus. These parts are removed by apoptosis in the embryo fingers that are all connected together initially: e. g. , occurs in the uterus during pregnancy. The hypertrophy and hyperplasia is reversed back to normal by apoptosis. Bcl2 is an anti-apoptotic protein that blocks apoptosis.
