PATH 300 Lecture Notes - Lecture 15: Thrombus, Diuretic, Rheumatic Fever

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Sa and av nodes generate impulses on their own: sa node is the pacemaker of the heart and generates impulses more rapidly and tends to control what happens. Its intrinsic rate of depolarization is higher than any other part of the heart. Its intrinsic rate is between 60-100 bpm: av node and h-p system have pacemaker activities, but they are slower. The av node has an intrinsic rate of 40-60 bpm. The ventricular system has an intrinsic rate of 20-45 bpm. There is insulation between the atria and the ventricles, so it is well controlled. The atria contract first, followed by the ventricles. The left ventricle conducting system consists of the left bundle braches and the purkinje fibers. There is a slow constant inward leak of na in between depolarizations. In the atria, the ion flux and shape of depolarization are different. There is almost an instantaneous depolarization, which leads to contraction, and then repolarization.

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