PATH 300 Lecture Notes - Lecture 19: Squamous Cell Carcinoma, Squamous Metaplasia, Small-Cell Carcinoma

• School: McGill University
• Department: Pathology
• Course: PATH 300
• Professor: Edith Zorychta

Document Summary

Deaths from lung cancer in canadian women have started leveling off, but no decline. Bronchogenic carcinoma: basal cells will multiply and produce squamous metaplasia, and eventually the carcinoma, metaplasia dysplasia anaplasia (carcinoma in situ) invasion metastasis. Small cell (oat cell) carcinoma small cells compared to normal that look like grains of oats. Adenocarcinoma carcinoma of gland or tissue. If you look at it under the microscope: usually divided into two major groups: small cell and non-small cell for treatment. Lung cancer subtypes: majority of cancers are non-small cell cancers, cells of origin include basal (sq) neuroendocrine (sm) alveolar (ad) The reason why we have different subtypes is because the cell origin is different. The squamous cell carcinoma originates from the basal cells that form the squamous cells. The small cell carcinoma evolves from a neuroendocrine-type cell in the lung. Location most common sites: peripheral location.