PATH 300 Lecture Notes - Lecture 24: Antibody, Aflatoxin B1, Kernicterus

• School: McGill University
• Department: Pathology
• Course: PATH 300
• Professor: Edith Zorychta

Document Summary

Diseases of the gi (part ii) liver. 50% comes from the hepatic artery (oxygenated blood): blood from the portal vein and hepatic artery exit via the central vein, portal triad, hepatocytes are in very close contact with blood flowing through the liver. Insulin, thyroxin, androgens, estrogens, etc. are all broken down: problems with hormone metabolism in the liver can lead to spider nevi. The monocyte takes up the rbc, and the liver takes up the bilirubin-albumin complex. Only when bilirubin is conjugated does it become water-soluble. In the intestine, conjugated bilirubin is modified by intestinal bacteria to become urobilinogen this makes stool brown: water soluble, conjugated form is reabsorbed into the blood from the liver and the intestine. It is excreted by the kidney, which makes urine yellow. If bilirubin is not properly excreted, jaundice can occur. Especially seen in the sclera, which contains a lot of elastin and collagen that can easily bind to bilirubin.