PHAR 303 Lecture Notes - Lecture 19: Endocrine Disruptor, Food Contact Materials, Michelle Obama
2 Apr 2017
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Phar 303 lecture 19: endocrine toxicology (robaire) Approximately 6 saqs worth 3pts each, fewer type c qs and more type a qs. Begins in the brain central gland = pituitary gland situated above the palate. Controls the thyroid, parathyroid, liver, pancreas, adrenals, bone, heart, adipose tissue, testes and ovaries: these tissues send input back to the pituitary. Androgens and estrogens are found in both males and females: androgens important for behaviour, follicular growth and atresia females, estrogens important for fluid absorption in the epididymis, bone development and sexual behaviour males. The hypothalamus communicates directly with the pituitary in order coordinate hormone release: hypothalamus releases small peptides (3-12aas in length) onto the pituitary. Da (not a small peptide: trh tsh thyroid t3 and t4, gnrh lh testes + ovaries, da negatively regulates prolactin (all others are positive regulators) The proteins stimulate hormones which feed back to regulate the axis at the hypothalamic or pituitary levels.
