PHAR 303 Lecture Notes - Lecture 1: Estrogen Receptor, Anterior Pituitary, Portal Venous System
9 Aug 2019
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These signals originate from higher brain centers: steroid hormone receptors are found throughout the brain, estrogens and androgens are made in the brain. They signal to the hypothalamus: the endocrine system and the nervous system communicate with each other quite effectively, the hypothalamus signals to the pituitary. They will enter the circulation and feedback to the pituitary, hypothalamus, or both: they will act on other tissues. There is also communication between tissues: thyroid and testes, adrenals and testes, adrenals and ovaries, estrogens can be made in fat. There are androgen and estrogen receptors in bone. 1: all body tissues respond to these signals, but the regulation of their synthesis (e. g. estrogen and androgens) is via the master control gland which is the pituitary. What is an endocrine disruptor: endocrine disruption can occur as a therapeutic or toxicological consequence, the most common therapeutic endocrine disruptor is contraception drugs.
