PHAR 303 Lecture Notes - Lecture 10: Edwin Smith Papyrus, Percivall Pott, Cancer
15 Feb 2018
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Document Summary
The exam will be 52 questions, mostly mc with 1-2 short answer questions. Some of the material is from chapter 8, but there is a lot of information that is supplemented from. If you want to challenge a question, you must challenge at least 3 other resources. Some basics: definitions, overview of the causes of cancer. Mechanism of action of chemical carcinogens: genotoxic vs. non-genotoxic. May involve inhibition of tumor suppressor genes and inhibition of apoptosis. It is a disease where normal cells are damaged: there will be abnormal growth of cells. There is dysregulation of the balance between cell proliferation and cell death: can also be called a malignant neoplasm. Cancer is associated with multiple changes in gene expression. It is the leading cause of death in the world, as well as in canada: 78,000 canadians will die of cancer in 2016. Mostly due to tobacco (25-40% of all human cancers) and adult diet/obesity.
