PHAR 562 Lecture Notes - Lecture 8: Axon Hillock, Resting Potential, Sodium Channel
12 Feb 2020
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Document Summary
Sodium channels contribute to the action potential (ap) rapid depolarization & are blocked by ttx: na+ channels are an essential part of aps in all excitable tissues (e. g. heart, skeletal muscle, neurons) Uneven distribution of na+ channels in neurons is critical to their roles in signaling: na+ channels are only found in particular sections of neurons. Along the axon: ap initiation normally occurs near the axon hillock where na+ channels are densely expressed. The na+ channel signaling complex is a multimer. Channel activation is triggered by the outward movement of s4 voltage sensors. Inactivation is due to the plugging of the pore by the inactivation lid of the diii-iv linker. 1) cork in a bottle : block the pore so ions can"t go through. Na+ channel blockers are used to treat different cns diseases. Several cns disorders are linked to mutations in different na+ channel subunits.
