PHAR 562 Lecture Notes - Lecture 3: Biological Neural Network, Rna Editing, Alternative Splicing
12 Feb 2020
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Wednesday, september 11th, 2019 lecture 3: iglurs & their synapses (kainate receptors, structural basis of activation) Nmdar + ampar = receptors involved in cns hardwiring, fundamental for brain function. Help ensure that neuronal functions are kept down unless they should be jacked up due to stress: kar system fine-tunes the behaviour of ampa + nmda receptors. In epilepsy: blocking kar could lower epilepsy symptoms without serious side effects. Pharmaceutically relevant: would be advantageous to develop a drug with kar blocking functions. I. e. rapidly open & close for each stimulus they receive, no summation: ampars: fitfully follow the signals coming into neurons, kars: synaptic response from kar is very small (i. e. why it took researchers so long to identify. However, a series of small responses build up/accumulate with time summation can this receptor) result in a even larger synaptic response than that produced by ampar. Critical for circuit function: depending on the frequency of signal synchronization, kars may/may not kick in.
