PHAR 562 Lecture Notes - Lecture 4: Dlg4, Ifenprodil, Grin2B
12 Feb 2020
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The simplified version: change in ampa and nmda receptor number and type. Everything get processed: you remember what is important to you and mentally paraphrase. Homeostatic mechanisms strengthens the synapse without changing overall firing rate of neurons. (thought to be one of the functions of sleep) Juvenile plasticity involves adding ampa receptors to the synapse: look at the neurons which do not express any ampa receptors initially who suddenly do. Silent receptors which are unsilenced : some silent synapses only have nmda receptors. Nothing happens at the synapse unless you get rid of the magnesium: silent synapses less common in mature tissue. The silent synapses are originally mediated by nmdars. The original nmdars in the silent, developing synapse is thought to be mostly glun2b homomers, whereas later nmdars are thought to be mostly glun2a and 2b heterodimers. Essentially, if a synapse is always stimulated, chances are it will have ampars. Maturation of the synapse: early period of low ampar signalling:
