PHAR 562 Lecture Notes - Lecture 15: Nicotinic Acetylcholine Receptor, Opioid Receptor, Naloxone
12 Feb 2020
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We left off with constitutive kos, and people thought the mice may have adapted from birth. Dat-mutated animals do not show cpp for cocaine: advantage: dopamine transporter still works normally, as seen in the graphs last class, could be a memory problem. Not the case: the mutated mouse can learn other cpps (ex: amphetamine cpp) The higher the number, the more the cocaine blocked. The highest dose was the highest that wouldn"t kill the mouse. 0,3 and 1 mg/kg were the robustly reinforcing doses: the results: mice. Reinforcing doses od iv cocaine only produced a little da uptake inhibition, even in wt. Dopamine doesn"t seem like it"s doing much: Unlike in humans, where occupancy was (very roughly) correlated with a high subjective is not the same as reinforcing. Dat block in humans is around 70% why do people respond at higher doses, or keep self-administering if the block is already high.
