PHGY 313 Lecture Notes - Lecture 2: Diabetes Mellitus Type 1, Neonatal Onset Multisystem Inflammatory Disease, Malaria
24 May 2016
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313 lecture 1: physiological functions of the hematopoietic system. Maintenance of tissue homeostasis and/or repair o o. Immune homeostasis (management of cell numbers before and after infection) Deregulation in the immune system or uncontrolled responses results in: o o o. Neutrophils have multi-lobed nucleus and many granules in cytoplasm. Horseshoe/kidney nucleus, one of the bigger types of cells. Large, round nucleus, little cytosol, no granules. Rbc (120 days), platelets (14 days), neutrophil (10h-5days) Production can increase 5-10 fold in case of injury/infection. Bone marrow is the primary site of hematopoiesis in adults: o. As you age, we get more yellow bone marrow, exercise can increase red bone marrow o o o. Highly complex, many components regulate blood cell production: Osteoblasts (bone producing cells), osteoclasts (bone degrading cells) In development, rbc is first found in yolk sac placenta (agm) fetal liver bone marrow. Properties of hematopoietic stem cells: multipotency=able to differentiate into all blood cell types, self-renewal=maintain cell numbers/functions in life.
