PHGY 213 Lecture 5: Endocrinology

• School: McGill University
• Department: Physiology
• Course: PHGY 213
• Professor: Melissa Vollrath

Document Summary

Insulin receptor: membrane receptor, stimulates insertion of cytoplasm"s glucose transport proteins stored into pm --increases glucose uptake: through glycolysis; atp production. In diabetic comas, acidosis & associated electrolyte imbalance must be corrected too. Insulin is a protein, can"t take as pill or body will think it"s food and will digest it. Insulin injection devices --need right amount since too much leads to passing out deficiency) Juvenile diabetes mellitus: appears in childhood, insulin-dependent, b-cells of pancreas don"t produce insulin, treat through insulin administration hyperinsulinism. In diabetic, greater increase in blood glucose and returns to normal more slowly: pretty definitive test. Control of insulin secretion: several feedback mechanisms --beta cells adjust insulin secretion depending on, also release of gastrin and vagal impulses to beta-cells induce insulin release blood glucose levels. Insulin starts to leave pancreas even before blood glucose rises during meals.