PSYC 211 Lecture Notes - Lecture 37: Substantia Nigra, Mptp, Selegiline
14 Jun 2016
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Treatment for pd: l-dopa replenishes the brain of its lost dopamine. In 1982; seven people in north california (mid 20s) were hospitalized for displacing dramatic clinical symptoms o total paralysis, no speech, constant drooling, eyes open with fixed stare, shuffling with slow gait. > parkinsons o: they had all taken a synthesized heroin (femoral) which contained mptp (1-mrthyl-4-phenyl- 1,2,3,6-tetrohydropyridine: primates treated with mptp show cell loss in substantia nigra, deprenyl blocks the effects of mptp. Alzheimer"s disease: alzheimer"s disease (ad) is characterized by progressive memory loss and other mental functions. Accumulation of b-amyloid in brains of alzheimers patients. The accumulation of amyloid plaques is caused by a defective form of b-amyloid: there are two forms of b-amyloid: a long and short form. In ad, the abnormally high concentration of the long b-amyloid causes them to misfold and aggregate which cause brain degeneration.
