BIOCHEM 2EE3 Lecture Notes - Lecture 10: Catabolism, Oxaloacetic Acid, Chlorophyll

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15 Mar 2017

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Phase 1 = glycolysis which occurs in the cytosol. Glucose is broken down from a six-carbon compound to two three carbon compounds called pyruvate. Oxidation of pyruvate occurs inside the mitochondrion and occurs in two stages. First conversion of the three-carbon pyruvate to a two carbon acetylcoa. Then oxidation of acetylcoa to carbon dioxide through the citric acid cycle. Oxidation of pyruvate to acetylcoa is catalyzed by pyruvate dehydrogenase (pdh) in the mitochondrion acetylcoa can be further broken down through the citric cacid cycle which is inside the mitochondrion. Citric acid cycle is a series of 8 reaction which break down the two-carbon acetylcoa to one- carbon co2 and generates 3 molecules of nadh, 1 fadh2 and 1 gtp. Nadh and fadh2 will go to the final stage of metabolism the electron transport chain. Through the electron transport chain the reducing equivalents will be converted to atp. Pyruvate dehydrogenase reaction and citric acid cycle are compartmentalized in the mitochondrion.

Related Questions

In glucose metabolism, glucose enters into the Glycolysis pathway. The products of glycolysis are then utilized by the Pyruvate Dehydrogenase Complex, which shuttles its products into the Citric Acid Cycle. The combined activities of these pathways directly synthesize a number of molecules of ATP, GTP, NADH and FADH₂. Indicate the net gain of each of the molecules listed in the table below if a single glucose molecule were to be completely and sequentially metabolized by all three processes.

Pathway	ATP	GTP*	NADH	FADH₂ / QH₂
Glycolysis
Pyruvate Dehydrogenase Complex
Citric Acid Cycle

fuchsiarhinoceros778

Carbohydrates are broken down into glucose monomer and dimers. Glucose is converted to pyruvate and then to acetyl CoA. Acetyl CoA enters the citric acid cycle and is broken down to CO2 and in the process produces NADH & FADH2, which is utilized in the generation of ATP via the electron transport chain. Why does the cell go through this elaborate pathway to convert glucose to carbon dioxide and water and in the process generate ATP? Why not use a simpler and shorter mechanism to breakdown glucose?

Which of the following is not a net product of the citric acid cycle for each molecule of pyruvate generated in glycolysis?

Select one:

a. 1 ATP (GTP)

b. 1 acetyl coA

c. 3 NADH

d. 1 FADH2

Question 2

Which of the following is NOT an end product for an acetyl group that enters the citric acid cycle?

Select one:

a. ATP

b. NADH

c. FADH2

d. oxaloacetate

Question 3

Once they have been processed through the citric acid cycle, the acetyl-CoA molecules from a single glucose molecule produce:

Select one:

a. 2 ATP, 6 NADH, 4 CO₂.

b. 6 NADH, 6 GTP.

c. 6 FADH₂, 2 ATP, 6 CO₂.

d. 6 GTP, 6 FADH₂.

e. 4 CO₂, 6 FADH₂, 2 ATP.

Question 4

The products of the citric acid cycle breaking down 2 acetyl-CoA include 2 ATP (converted from GTP), 6 NADH and 2 FADH2.

Select one:

True

False

BIOCHEM 2EE3 Lecture Notes - Lecture 10: Catabolism, Oxaloacetic Acid, Chlorophyll

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