BIOCHEM 2EE3 Lecture Notes - Lecture 3: Heterocyclic Compound, Imidazole, Hydrogen Bond

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2 dna strands - interact via non-covalent hydrogen bonds. G and t cannot bind together because the cannot make hydrogen bonds because they do the same geometry and disturb the helix. Stacking interactions - pi pi - van der waals - allow for stability. Due to two grooves dna can act in a specific or non specific manner. Made up of building blocks called nucleotides that are covalently linked to one another vi. 5" phosphate of one nucleotide and 3" hydroxyl of another monomer. Nucleotide ey don"t have er via phosphodiester bond. Purine structure - heterocyclic aromatic organic compound, pyrimidine ring fused to an imidazole ring. Heterocyclic aromatic organic compound contain pyrimidine ring fused to imidazole ring. Strong acid with pka = 1, that"s why dna and rna are acidic. At physiological ph carries a net negative charge. Dna will have on end with a free phosphate group because it is a linear molecule, this is t.

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