BIOCHEM 2EE3 Lecture Notes - Lecture 11: Hmg-Coa Reductase, Glycerol, Acetyl-Coa
8 Apr 2018
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Document Summary
Coa via beta oxidation glycerol moiety (part of triglyceride) is also usable as energy and leaves adipose to be taken up by liver - where gluconeogenesis happens glycerol substrate for gluconeogenesis. Activation of fatty acids in cytosol fatty acyl-coa is transported into mitochondrial metric need to activate fatty acid bc can add long chain hydrocarbon of fatty acid to coa catalyzed by acylcoasynthase. "acyl" group is portion of fatty acid bound to coa reaction takes place in cytosol and acylcoa ready to be primed and transported to mitochondrial matrix. Same thing as products of glycolysis and pdh reaction it enters tca and is further oxidized and broken down to. Synthesis of fatty acids in cytosol similar to b-oxidation of fatty acids but in reverse consumers nadph instead of nadh or fadh2. 1 atp consumed per round of acetylcoa addition to the elongating fatty acid one palmitate made for every 8 acetyl-coa.
