BIOCHEM 2EE3 Lecture Notes - Lecture 3: Exergonic Reaction, Ramachandran Plot, Glutamine
6 Mar 2014
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Therefore only the ends are ionized, not groups in the peptide: memorize this and structures of amino acids, do not know one letter code, know that each capital letter in word designates amino acid. Tryptophan is conserved in amino acids usually does not change in various organisms: oh, cooh, nh2 groups indicate polar, not ionisable therefore non-charged at physiological ph, polar groups allow formation of h bonds. Ligand: any small molecule that can bind: all drugs are ligands, glutamine can form 4 h bonds, cysteine: 1 h bond, difference between ionizable/ionized ionizable does not say whether amino acid is ionized because it depends on. Interactions between these are stronger than polar amino acids environment. 5% of ionizable molecules not ionized at physiological ph due to equilibrium. Important that you cannot superimpose l/d configurations of amino acids because of chiral centre: red indicates side chain.
