BIOCHEM 4M03 Lecture Notes - Lecture 13: Prostaglandin, Nutrient, Chromosome

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Biochem 4m03 lecture 13 a vitamin & fat metabolism. Outcome is not always disease but focus on disease often. An example of how a micronutrient alters metabolism. Retinoic acid: nuclear receptors: rar, rxr, ppar, gene transcription. Vitamin a: preformed vitamin a (comes from animal sources) Foods of animal origin: liver, dairy, eggs, fish, fish oils. Preformed types of vitamin a: retinol, retinal (retinaldehyde) and retinoic acid. Biological processing of carotenoids: need to process preformed sources of vitamin a to get sources you find from animals or in us, arrows are interchangeable. 1 unit of retinol (from animals: need 12 times the amount of (cid:533)-carotene, (cid:533)-carotene supplements can be more potent (2 times the amount) 1) eat meat, fat, carrots (preformed vitamin a) 2) goes into lumen of the gut. 5) repackaged so that we can absorb it. 6) have types of vitamin a can have effects or be stored. 7) beta-carotene can be processed to from retinal.

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