BIOTECH 3PM3 Lecture Notes - Lecture 5: Cholinergic, Adrenergic, Postganglionic Nerve Fibers
4 Dec 2017
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Mcmaster university biotech 3pm3 pharmacology week 05. When the sympathetic division is stimulated, all sympathetic nerves are activated at the same time. When the parasympathetic division is stimulated, only selected nerves can be stimulated. When discussion the ans nerves, we focus on the peripheral efferent (motor) side. The autonomic nerve pathway involves two nerves cells. One is located in the brain or spinal cord. The other is within a group located on the effector organ. The main pharmacological difference between the two is that neurotransmitter released by their postganglionic nerves. Norepinephrine is stored in the adrenergic nerve endings. When the nerve is stimulated, norepinephrine is released. Ne can be reused or destroyed in the nerve endings. Both stimulate internal organs to increase sympathetic activity. Epi is produced and released from the adrenal medulla. Epi relaxes smooth muscles, but ne does not. Because of differences in responses produced by ne and epi, serval adrenergic receptor types have been identified.
