HTHSCI 1DT3 Lecture Notes - Lecture 4: Almroth Wright, Hepatitis B Vaccine, Polio Vaccine
13 Aug 2020
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Mod. 3-16 an introduction to vaccines 1. Bcg is effective against the more severe form of tb, known as mtb. The bacteria is regrown in a stressed environment and loses its virulent genes. Able to prevent some antigens of tb in a less infectious way. Rabies virus and mmr: subunit/fractionation breaking up the bug and taking fragments of it e. g. non-replicative purified subunit. Inactivation vaccine treated to make it less infectious e. g. inactivated vaccine. Mod. 3-16 an introduction to vaccines 2. Ting joe li yah: newer vaccine uses virulent parental pathogen. Virus-like particles, where the virus express capsid proteins, but there is no gene inside an empty virus e. g. hpv. Vaccine immunology: vaccine stop infection (generating immune memory in absence of harmful infection), prevention of entry. Neutralisation: iga, a non-inflammatory ab in the mucosal binds to pathogens and prevent them from binding to host cells (virus can recognise cell surface receptor)
