HTHSCI 1DT3 Lecture 6: Immunology_Lec6_Engineering T Cells_Dr. Branson2
4 Mar 2016
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Proteins normally not expressed at all (only expressed in germ cells)> become upregulated, expressed in cancer cells (mage proteins) Cancers can"t be all linked to viruses. Hpv linked to cancer, and other squamous (head and neck) cancer. Inside cell, proteins constantly being degraded, constant immune surveillance, Cleaved by proteases > peptides, presented to immune system by mhc: only fragments of given protein are displayed: how t-cell sees inside the cell (impossible through the membrane, thus must be presented) T cells surveil these complexes all the time, look for ones that are good ts to receptors. Finding key t: production of cytokines, release of cytotoxic mediators: proteins that can poke holes in target cells> cause cell destruction, t-cells don"t directly interact with these targets, tcr: Binds both to self (mhc) and what could be foreign (peptide: normal peptide vs. un-normal peptide in virus infected cells (leave alone vs. reacting) Each t cell has a unique tcr.
