HTHSCI 1LL3 Lecture Notes - Lecture 9: Pyrene, Helicase, Dna Mismatch Repair
22 Jun 2018
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DNA SYNTHESIS
D§.
§§
cell cycle
•
Inter phase is made up of stages Gi ,
S
,and Gz
-
During the Sphale of the cell cycle DNA is replicated and histone and other protein synthesis
is Increased
-
After Gz there Is acheckpoint which checks whether DNA is replicated completely and
correctly
>Mutation =bypassing of check Phan
•
Mitosis is the Mphase
•
Once replicated and divided ,cells can further divide or can enter a resting phase 1Go )where
they can stay (nerve cells)or be Induced back Into the cycle through ashmulw 1liver cells )
Mitosis
•ldet ')starting with asingle set of 46 chromosomes →
duplication →divided into two cells
•Meiosis :mitosis with another set of division for sex cells
so that there's one set of chromosomes in each
DNA replication
DNA Replication MHOS "2diploid cells
•
DNA replication Is semi conservative (decreases chance of mutation )
-
semi come native replication : opening up of the double helix and each strand Is
copied Individually from information in other strand
Bacterial Replication
•
Bacterial cells have circular DNA ,
with an origin
•the main is the place that DNA replication begins in both directions /
-
Origin opens ,polymerase enters ,and pro cede from either side ,treating two new
"
sets
•
The Urculav nature of bacteria DNA and its single origin are acouple of the dithhniy between
Prokaryotic and eukaryotic DNA replication ,
Eukaryotic Replication
•There are multiple origins of replication L
•
Replication bubbles arise at points along the DNA and synthesis proceeds as afork 1h each direction
•The new strand is formed from the template of the old on each strand .
'
. semi conservative replication
Document Summary
Inter phase is made up of stages gi , During the sphale of the cell cycle dna is replicated and histone and other protein synthesis is. Once replicated and divided cells can further divide or can enter a resting phase 1 go ) where they can stay ( nerve cells) or be. Into the cycle through a shmulw 1 liver cells ) Mitosis ldet ") starting with a single set of 46 chromosomes duplication divided into two cells. Meiosis : mitosis with another set of division for sex cells so that there"s one set of chromosomes in each. Dna replication is semi conservative ( decreases chance of mutation semi come native replication : opening up of the double helix and each strand. Is copied individually from information in other strand. Dna with an origin the main is the place that dna replication begins in both directions. Origin opens , polymerase enters and pro cede from either side.
