HTHSCI 2H03 Lecture Notes - Lecture 15: Locus Coeruleus, Raphe Nuclei, Major Depressive Disorder

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: kirsten

Document Summary

Pharmacology of the central nervous system drugs for mood disorders. Over 100 different neurotransmitters have been identified in the central nervous system. 3 major classes: small molecule neurotransmitters (e. g. dopamine, neuropeptides (e. g. substance p, neurotransmitter gases (e. g. nitric oxide) Small molecule neurotransmitters: acetylcholine, monoamines, dopamine (da, norepinephrine (ne, epinephrine (e, serotonin (5-ht, amino acids, glutamate, gaba. Norepinephrine (ne: neurons originating from the locus ceruleus project to limbic system & cerebral cortex, 2 receptor classes: alpha & beta, maintains emotional tone (mood, arousal, wakefulness & reward, metabolized by enzyme mao. Lack of adequate serotonin in the cns can lead to depression: metabolized by the enzyme mao. Persiste(cid:374)t distur(cid:271)a(cid:374)(cid:272)e i(cid:374) (cid:373)ood that i(cid:373)pairs a perso(cid:374)"s a(cid:271)ility to effe(cid:272)ti(cid:448)ely deal (cid:449)ith (cid:374)ormal activities of daily living. Lack of energy: sleep disturbances, abnormal eating patterns, feelings of despair, guilt or hopelessness, most common mental health disorder of older adults, encompasses physical, emotional, cognitive and social factors.