KINESIOL 1AA3 Lecture Notes - Lecture 13: Hypothermia, Brainstem, Vagus Nerve

• School: McMaster University
• Department: Kinesiology
• Course: KINESIOL 1AA3
• Professor: Krista Howarth

Document Summary

Co2: co2 converts to carbonic acid & becomes h+ and bicarbonate ions & lowers ph. Co2 + h2o ca > h2co3 h+ + hco3- Temperature and oxygen affinity for hgb: metabolism=heat as by-product, as temperature increases, more o2 is released, hypothermia metabolism slows, less o2 released. Effect of bpg: 2,3-bisphosphoglycerate(bpg): released by rbcs as they break down glucose for energy, binds to hemoglobin and increases release of oxygen. 3 forms of transport: dissolved co2 7% dissolved in blood plasma, carbaminohemoglobin (23%): hgb + co2 hgb-co2. Hemoglobin that has released oxygen binds more readily to carbon dioxide than hemoglobin that has oxygen bound to it (haldane effect: bicarbonate ions (70%): At tissue level we have increased c02 levels move toward into plasma taken up in rbc, carbonhydronase reaction for bicarbonate bicarbonate taken out of membrane (chloride shift) and puts chloride inside to balance negative charge (by anti porters) H+ binds on to hemoglobin, affinity for 02 drop (bohr effect)