PSYCH 2AP3 Lecture Notes - Lecture 7: Clomipramine, Basal Ganglia, Model Organism
22 Nov 2015
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Argues that washing compulsion is a built in, ancient grooming program that has been elevated to an inappropriate degree in ocd ppl: checking. Is a result of checking for predators in our environment: acral lick disorder in dogs. Dogs lick their fur so much, they end up with patches of fur missing. Argues this is an animal model of ocd: we don"t know if it is an obsession (bc we can"t determine what the thoughts are for dogs, we do know that this is a compulsion for dogs. Clomipramine is the most effective drug to eliminate acral lick: clomipramine is the single most drug that treats human ocd, this is why we look at acral lick as a model to understand human. We know acral lick is controlled by basal ganglia activity. It"s not about the proportion of individual symptomatology; it"s about.
