BCHM 316 Lecture Notes - Lecture 13: Cholesteryl Ester, Ester, Coenzyme A
23 Feb 2018
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As a fa enters a mitochondria, it is broken down. ( it doesn"t leave). Fas on albumin and glycerol are exported to liver and/or muscle. Fas are weak acids, ionized at cellular ph (~7). However, 95% is bound in blood/cell. (so free carboxyl group is tied up). Albumin bound fas free fa tg & ce in lipoprotein. We want to convert our fa into an esterified form, so that it will be inactive. Co-ash + hooc-r2 coenzyme a -s-c (=o)-r2 or fatty acyl coa. Coa-sh + fatty acid + atp amp + ipp ( 2 phosphate bonds cleaved) + fatty acyl-coa. There"s an intermediate (fatty acyl adenylate enzyme-bound) Pyrophosphate 2 pi via pyrophosphatase; drives reaction. Only binds one fa, protects it from the environment (clam shell) There are 3 parts to carnitine transport system. Blue pink and blue, not connected like they appear but they do work in sequence one after the other.
