MICR 221 Lecture Notes - Lecture 23: On2 Technologies, Virus, Capsid

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 221
• Professor: Eric B Carstens

Document Summary

Structural unit: vp1 associated w/ vp3 and vp2 (triagles) See a certain arrangement of vp1 (blue) 5 polio virus protomers (structural units) assemble to make a pentamer (assembly unit), introducing curvature to the pentamer. Way that virion develops is spherical structure is through the interaction of the 5 pentamers forming a curved structure w/ 5 vp1s at the vertex. See 12 pentamers make up cpasid long arms are how pentamers interact w/ each other. Sv40 assembly unitssv40 pentamer: made up of 5 vp1 r protomers. In emc image see lumps on outside of blobs: capsomeres. 12 fibres each w/ a penton base (12 bases in total) If try to denature will start to fall apart at penton base, then hexon, but ninemer will stay together. Variety of capsomeres- see vp1 arranged as a pentamer. In this case have 60 on face and have special pentamers at the vertex (12 in total) If look at non vertex pentamer: have 6 neighbours.