MICR 360 Lecture Notes - Lecture 7: Adaptive Immune System, Cd14, Transforming Growth Factor Beta
22 Dec 2018
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Document Summary
Clearance of pathogens can be accomplished via early induced innates responses, involved rec of molecular patterns on microbes. Expressed by innate, adaptive and other cells (endothelial) Act by damps and pamps (ligands) intracellular signaling pathway act + mod of gene expression (ex. cytokine genes that control inflam) Have defined role and location, nuclear or cytosolic (reg of mito) Bind to a wide range of prrs to initiate inflame response. Horse-shoe structure made of leu rich repeats for ligand binding + intracell cytoplasmic tail for signal trans. Need ligand to induce an intra signal effects. On surface of cell (pm), rec lps in gram -ve bacteria. Lps binds cd14 + uses lps binding protein cd14 takes lps to tlr4 which homodimerizes to bind lps intra signaling pathway act of nf-kb transc factor inflame cytokines. Cytokine expression: mod inflame, recruit and act innate and adaptive immune cells.
