MICR 360 Lecture Notes - Lecture 2: Cytotoxic T Cell, Chemotaxis, Natural Killer Cell

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

Breaks down peptidoglycan molecules found in the cell wall of gram- positive bacteria. Gram positive bacteria = has a thick layer of peptidoglycan. Breaks bonds that hold pg (peptidoglycan) together. Defensic = creates leaky membrane in bacteria; creates pores. Macrophage and endothelial cell release of cytokine and chemokines attract other immune cells and kill the microbe; causing vasodilation and increasing capillary permeability. Aka large granular lymphocytes secrete cytokines such as ifn and tnf , which act on other immune cells like macrophage. &dendritic cells to enhance immune response https://www. immunology. org/public-information/bitesized-immunology/cells/natural-killer- cells. Nk cells can kill tumour cells w/o any prior activation unlike cytotoxic t cells natural killing. Vasodilation facilitates fluid entry into tissues fluid accumulates at infection site fluid contains chemotactic factors chemotactic factors induce the recruitment of more immune cells to the site of infection immune cells include neutrophils. At the site of infection, immune cells adhere to the endothelial cell walls and migrate into infected tissues via extravasation.