PHAR 100 Lecture Notes - Lecture 2: Neuromuscular Junction, Autonomic Nervous System, Nicotinic Acetylcholine Receptor
17 Jun 2016
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Document Summary
Recognize change in the environment (carry signals to the brain) ex. All drugs target motor neurons, not sensory neurons. Releases acetylcholine which bonds to receptors, causing the muscles to contract. It interacts with nicotinic receptors on skeletal muscle: neuromuscular junction; the nerves interact with the muscles rather than nerve to nerve. Few drugs target skeletal muscles: most of them interfere with neurotransmission at the neuromuscular juntion o. Inhibits muscle contraction; but almost to the point where they"re in a coma. Controls response by organs, glands, and smooth muscle. Released into synaptic cleft when an action potential arrives. Two neurons required to reach target organ: ganglia- mass of nerve cell bodies. Preganglia (before) postganglia (after: all autonomic ganglia have nicotinic receptors, all target organs of the parasympathetic nervous system have muscarinic receptors. Direct acting agents: interfere with n or m receptors. Indirect acting agents: bind to and inhibit ach increasing the concentration of ach.
