BLG 888 Lecture Notes - Lecture 3: Silent Mutation, Null Allele, Methyl Group
16 Jan 2017
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Document Summary
Nad+ and nadp+ plays crucial role in energy production, lipid and nucleic acid synthesis and photosynthesis. Point mutation: changes a single base pair. Gain of function mutations: generally dominant silent mutation: no apparent effect loss of function mutation: eliminates or reduces activity of the gene product chemical modifications of nucleotide bases: Methylation- adding a methyl group to acquire. Deamination- removal of an amine group- adenine, guanine, cytosine (oxygen replaces amine, turning it into uracil)-this activates dna repair mechanisms that will correct the wrong base and replace it with the right one cytosine deamination: Provides innate cellular defence against viral infection. Apobecs (apolipoprotein b mrna editing enzyme, catalytic polypeptide like) family of human proteins: catalyze cytosine deamination in viral genome during an initial round of replication of. L vs d forms: l form is more common, where r group faces outwards (towards us) functional groups affect reactivity: R-groups differ in their size, shape, reactivity, and interactions with water.
