MBB 222 Lecture Notes - Lecture 4: Lone Pair, Disulfide, Hydrogen Bond
20 Dec 2018
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Document Summary
Covalent bonds hold building blocks together in proteins and nucleic acids. Note: covalent bonds also hold atoms together within amino acids and nucleotides. Disulfide bonds (aka disulfide bridges) are covalent bonds between thiol groups on the side chains of the amino acid cysteine that hold different parts of the polypeptide backbone together stabilize the protein fold. Are crucial for most cellular processes e. g. , dna replication, protein folding, protein- protein interactions. Weak bonds, transient interactions allow for very dynamic systems. Individually these bonds are weak but cumulatively they can be very strong. Hydrogen bonds: between an h atom covalently attached to an electronegative atom (a hydrogen bond donor, usually o or n) and a second electronegative atom that serves as h bond acceptor (also usually o or n). The h-bond forms between the hydrogen atom on the donor and the lone electron pair on the acceptor.
