BIOCH200 Lecture Notes - Triosephosphate Isomerase, Dihydroxyacetone Phosphate, Atp Hydrolysis
10 Apr 2014
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Bioch 200 glucose metabolism (march 31, 2014: the glucose metabolism pathway will be talked about in detail, energy investment steps, glucose glucose-6-phosphate (g6p) This step is irreversible but it does not lock down the glycolysis pathway. Costs 1 atp molecule: glucose-6-phosphate (g6p) fructose-6-phosphate (f6p) These two molecules are actual structural isomers. What actually happens (isomerization): glucose-6-phosphate loses ring formation, glucose-6-phosphate isomerase turn it into fructose-6-phosphate (no atoms are lost or gained) moves around atoms to, fructose-6-phosphate transforms into ring conformation, fructose-6-phosphate (f6p) fructose-1,6-bisphosphate (f-1,6-bp) Rate-limiting and is the committed step in glycolysis. Rate limiting and tightly-regulated: f-1,6-bp dihydroxyacetone phosphate (dhap) + glyceraldehyde 3- phosphate (gap) Since this yields a nadh, which can later be used as an electron source for the etc to generate atp, this is an energy capture. It"s because this step is coupled to another step that required 1,3-bpg.
