BIOCH200 Lecture Notes - Lecture 29: Phosphofructokinase, Hexokinase, Allosteric Regulation
4 Dec 2016
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Biochem 200 - lecture #29 - regulation of glycolysis. Glycolysis is regulated: ensures energy needs are met, glucose is not waster when atp is abundant. Intermediates may be used in other processes and reactions. Sometimes glycolysis needs to be suppressed in order to regulate the irreversible reaction. The rate of flux through metabolic pathways is regulated by four major processes: substrate availability, alteration of enzyme activity. Allostery, phosphorylation: alteration of the amount of enzyme. An overview of glycolysis regulation: concentration of intermediates reflect energy need/consumption. Acts as a negative, allosteric effector for hexokinase. An example of product inhibition, where the enzyme is inhibited. Directly by the product: pfk-1 is allosterically regulated by. Adp and amp are heteroallosteric activators for pfk-1. Adp and amp also acts as a signal to indicate that energy is consumed and whether there is a need for atp. (cid:1371) [pep] signal that the products of glycolysis are not being consumed.
