MBG 1000 Lecture Notes - Lecture 29: Hair Follicle, Growth Factor, Paclitaxel

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 1000
• Professor: Georgevander Merwe

Document Summary

Brca1 and associated proteins are recruited to the dsb. Rpa is a protein that binds ssdna. Rad51 = enzyme that repairs the dna break by using the intact sister chromatid as a template for homolgous recombination. *in summary if a dna strand breaks, the one strand of the double stranded dna needs to be repaired. *he went over this 3 times so it"s important he said just make sure you know the cycle well, don"t have to know the specifics about each protein) Germ line mutated alleles of dna repair genes. Functions as a tumour suppressor and dna repair genes. Many lead to shortened, dysfunctional brca1 protein. Cancer treatment may be given for a number of reasons. Sometimes, the goal of treatment can change over time. Prevention: treatment is given to prevent the growth of cancer cells or to remove precancerous tissue that could turn into cancer. Cure: treatment is given to cure cancer.