MBIO 2360 Lecture Notes - Lecture 15: High Fidelity, Dna Replication, Nucleic Acid Thermodynamics
1 Dec 2016
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Nucleic acids (polymers of nucleotides: deoxyribonucleic acid (dna) Nucleosides: sugar (pentose, purine or pyrimidine base, draw. Nucleotides: basically nucleosides with a phosphate. Draw: note: pentose c numbers are given a prime to distinguish them from the base numbers, the phosphate oxygens have pkas of about 1 and 6, so are ionized at ph 7. The bases: purine and pyrimidine - parent compounds for nucleosides and nucleotides. Carbon and nitrogen are numbered with regular numbers, e. g. n1, c2, not including primes. Connection to sugar is n1 on pyrimidine and n9 on purine: adenine and guanine: the two purine bases, cytosine and thymine: the two pyrimidine bases, uracil is the pyrimidine base that substitutes for thymine in rna. Draw: many other bases are known but most are rare. The bases are coupled to c1" of the sugar via a beta-linkage with n9 of a purine or n1 of a pyrimidine.
