MBIO 2370 Lecture Notes - Lecture 3: Phosphoenolpyruvate Carboxykinase, Pyruvate Carboxylase, Anaplerotic Reactions
2 Feb 2017
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Document Summary
Has the potential to be a chiral molecule - based on the way it fits in the active site: even though it has symmetry. It fits only one way into the active site of the enzyme. Producing only one product every single time. Glucose + 6o2 -> 6co2 + 6h2o. Not necessarily the shortest by is it the most advantageous: provides the maximum advantage. Before the advent of aerobic organisms, anaerobic bacteria had incomplete tca cycles. With the formation of an o2 atmosphere, selective pressure forced aerobic metabolism which is much more energy efficient. Many intermediates in glycolysis and tca cycle are needed by other pathways: used to make other molecules. Intermediates must be continually replenished: they are used for other purposes. Anaplerotic = balancing or filling up reactions: they feed oaa into the tca cycle. Tca and glycolysis intermediates can be interconverted. Can work in gluconeogenesis to form glucose. This is anaplerotic and has a role in c4 plants.
