MBIO 2370 Lecture Notes - Lecture 7: Succinyl-Coa, Citric Acid Cycle, Gluconeogenesis
14 Feb 2017
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How much atp is generated from tristearylglycerid (triglyceride with 3 stearic acid groups - c18) Tca: gtp, 1 fadh2, 3 nadh. 27 accoa: 81nadh, 27fadh2, 27 gtp. Review of the catabolism of the fatty acid stearate. It changes when you add the water: the last acetyl coa will have all t, all the others will have 2:1 for h:t. Comparison of energy production from glucose and triglyceride. How many atp from 1 tristearylglyceride: 378. 5 x 30. 5 = 11,544. 25 kj/mol. The cis double bond in this position prevents dehydrogenase from forming bond between atoms 2 and 3. Isomerases fixes this by shifting the double bond between atoms 2 and 3, forming a trans isomer: the reactions are then the same as saturated fa"s starting with enoylcoa hydratase. Compared to stearic acid there would be one fadh less produced, because the acyl-coa dehydrogenase step is not needed: 1 less fadh2 per double bond.
