MBIO 2420 Lecture Notes - Lecture 15: Hepatitis B Virus, Rabies Virus, Horizontal Transmission
7 Dec 2016
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Document Summary
Some virus targets specific tissues and/or cell types. This can be accomplished by cell surface receptor recognition: viruses have evolved to take advantage of these receptors, cd4+ t cells infected by hiv. Evolved to bind to this receptor: car and integrins act as the receptor for adenovirus 5 for infection of epithelial cells. The big picture: a common strategy, unity in diversity. Permissive - can replicate: all viral genomes are able to establish themselves in a host population so that viral survival is ensured. There is an underlying simplicity and order to viruses because of two simple facts: all viral genomes are obligate molecular parasites that can only function after they infect a cell. Genome does all - causes all the infections. The big bag wolf: all viruses must make mrna that can be translated by host ribosomes: they are all parasites of the host protein synthesis machinery.
