BIOL308 Lecture Notes - Lecture 21: Zebrafish, Ptpn6, Pearson Education
4 Feb 2015
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Extreme form of rna editing - many nucleotides: rna editing in mitochondria of protozoa, mitochondria and chloroplasts in plants: Addition or deletion of u residues - guide rnas (grna) Rna sequence is altered in a single-nucleotide, site specific, manner: rna editing in mammals. Rna editing in mammals: rna sequence is altered in a single-nucleotide, site- specific, manner. Deamination of a to i (inosine: this is (mostly) happening on un- spliced rna template due to specific secondary structure of. Rna (self-complementarity: in translation i is recognized as g. Change in the aa sequence of the protein. Synthesis of apolipoprotein-b proteins (apob), components of serum lipid carrier proteins; present in liver and intestine. Enzymatic complex: cytidine deaminase, apobec1 (apob mrna-editing enzyme catalytic polypeptide 1), and auxiliary factor acf (apobec1 complementation factor); bind to specific rna sequences. Apo-b100 and apo-b48 mrnas - transcribed from the same gene. In a liver the entire apo-b100 is synthesized. In an intestine the existing mrna is changed:
